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Research Article
Tiapride in levodopa-induced involuntary movements.
  1. A J Lees,
  2. C M Lander,
  3. G M Stern

    Abstract

    Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning of "off-period" segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.

    https://doi.org/10.1136/jnnp.42.4.380

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