Fornix and Hippocampal Atrophy in Traumatic Brain Injury
Abstract
This study compared a fornix cross-sectional-area measurement and hippocampal volume in 86 traumatic brain injury (TBI) subjects with 46 normal controls. The TBI group showed a significant reduction in fornix area and hippocampal volume. It was also shown that initial injury severity was related to the degree of atrophy in both structures. Although fornix size and hippocampal volume correlated, such a modest correlation between these two structures suggests differential and potentially independent mechanisms of injury. The General Memory Index score from the Wechsler Memory Scale–Revised was shown to be significantly correlated with hippocampal volume following TBI.
Footnotes
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↵1 Corresponding author.
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E-MAIL erin_bigler{at}byu.edu; FAX (801) 378-7862.
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Article and publication are at www.learnmem.org/cgi/doi/10.1101/lm.33000.
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- Received May 9, 2000.
- Accepted September 8, 2000.
- Cold Spring Harbor Laboratory Press
