The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism
Stephan Klebe, Jean-Louis Golmard, Michael A Nalls, Mohamad Saad, Andrew B Singleton, Jose M Bras, John Hardy, Javier Simon-Sanchez, Peter Heutink, Gregor Kuhlenbäumer, Rim Charfi, Christine Klein, Johann Hagenah, Thomas Gasser, Isabel Wurster, Suzanne Lesage, Delia Lorenz, Günther Deuschl, Franck Durif, Pierre Pollak, Philippe Damier, François Tison, Alexandra Durr, Philippe Amouyel, Jean-Charles Lambert, Christophe Tzourio, Cécilia Maubaret, Fanny Charbonnier-Beaupel, Khadija Tahiri, Marie Vidailhet, Maria Martinez, Alexis Brice, Jean-Christophe Corvol, French Parkinson's Disease Genetics Study Group and the International Parkinson's Disease Genomics Consortium (IPDGC)
Journal of Neurology, Neurosurgery & Psychiatry Jun 2013, 84 (6) 666-673; DOI: 10.1136/jnnp-2012-304475