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Familial centronuclear myopathy
  1. W. G. Bradley1,
  2. D. L. Price,
  3. C. K. Watanabe
  1. Department of Neuropathology, Massachusetts General Hospital, Boston, Mass.
  2. The Department of Neurology, Harvard Medical School, Boston, Mass.
  3. The Department of Medicine, Highland General Hospital, Oakland, California, U.S.A.


    The clinical and histological features of two Negro brothers with a centronuclear myopathy are described. They bring to 19 the number of cases now reported with this constellation of physical signs and pathological changes in the muscles. A review of these patients suggests the existence of several different diseases causing this picture, though presumably the underlying biochemical defects are closely related. It is concluded that these myopathies are degenerative rather than due to arrest of foetal muscle maturation.

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    • 1 Current address and address for reprints: Muscular Dystrophy Group Research Laboratories, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE.