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Uptake and release of 14C-5-hydroxytryptamine by platelets in affective illness
  1. David M. Shaw,
  2. David A. MacSweeney,
  3. Norman Woolcock,
  4. A. B. Bevan-Jones
  1. Medical Research Council Neuropsychiatry Unit, West Park Hospital, Epsom, London
  2. Carshalton Surrey, St. Bartholomew's Hospital, London
  3. The Department of Psychological Medicine, St. Bartholomew's Hospital, London


    In the search for paradigms of postulated abnormalities in indolamine function in the brain in affective disorders, 5-HT uptake and release was estimated in platelets from patients suffering from severe depressive illness. Neither of these measures was altered by the illness and the most likely explanation for the negative findings was that in this setting platelets are not a suitable model.

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