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Visually evoked responses in multiple sclerosis
  1. E. T. Richey2,
  2. K. A. Kooi,
  3. W. W. Tourtellotte
  1. Laboratory of Electroencephalography, Neuropsychiatric Institute, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A.


    Visually evoked cerebral responses (VERs) from the occipital and central areas were compared between 50 patients with multiple sclerosis and 50 control subjects. The average peak latencies of four occipital components (OII-OV) and two central ones (CIV and CV) were significantly delayed. In no instance was the amplitude significantly different. Routine EEGs were either entirely normal (16) or showed only minor findings (10) in 26 patients. Of this group, nine showed abnormal VERs. Seventeen patients had clinical symptoms or signs which pointed to spinal cord involvement only; nonetheless, eight in this group had abnormal responses. Inasmuch as changes in visually evoked potentials are not directly dependent upon the presence of a demonstrable field defect, the technique may be useful in detecting otherwise occult cerebral lesions.

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    • 2 Present address: Jackson Memorial Hospital, University of Miami Medical School, EEG Laboratory, Miami, Florida 33136, U.S.A.

    • 1 Supported in part by research grant NB-02560 from the National Institute of Neurological Diseases and Blindness, U.S.P.H.S., National Institutes of Health, and a grant from the Michigan Chapter of the National Multiple Sclerosis Society.