Article Text

Download PDFPDF
Myasthenia gravis occurring in twins
  1. T. Namba1,
  2. M. S. Shapiro,
  3. N. G. Brunner,
  4. D. Grob
  1. Department of Medicine, Maimonides Medical Center and State University of New York Downstate Medical Center, Brooklyn, New York, U.S.A.


    Myasthenia gravis in one member each of two sets of twins is described. A 17 year old girl developed generalized myasthenia gravis at the age of 14 years, while her monozygotic twin sister has remained in good health during a three year period of observation. Another patient was a 19 year old woman with the onset of generalized myasthenia gravis at the age of 11 years, and her dizygotic twin sister has been in good health.

    Myasthenia gravis has been described in 13 sets of monozygotic twins, seven sets of dizygotic twins, and one set of twins with undetermined zygosity. Both members of twins were affected in five sets of monozygotic twins and one set of twins with undetermined zygosity, and only one twin was affected in the remaining sets of twins. Occurrence of myasthenia gravis in both members of monozygotic twins and in none of dizygotic twins, and frequent familial occurrence of the disease suggest the role of a genetic factor in the pathogenesis of this disease.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


    • 1 Address for reprints: Dr. Tatsuji Namba, Maimonides Medical Center, Brooklyn, New York 11219, U.S.A.