Article Text

Download PDFPDF
Raised intracranial pressure and cerebral blood flow
  1. I. H. Johnston,
  2. J. O. Rowan,
  3. A. M. Harper,
  4. W. B. Jennett
  1. Institute of Neurological Sciences, Glasgow
  2. The Wellcome Surgical Research Institute, Glasgow
  3. The M.R.C. Cerebral Circulation Research Group

    I. Cisterna magna infusion in primates


    Changes in cerebral blood flow during incremental increases of intracranial pressure produced by infusion of fluid into the cisterna magna were studied in anaesthetized baboons. Cerebral blood flow remained constant at intracranial pressure levels up to approximately 50 mm Hg. At intracranial pressure levels between 50-96 mm Hg a marked increase in cerebral blood flow occurred, associated with the development of systemic hypertension and changes in cerebrovascular resistance. Further increases of intracranial pressure led to a progressive fall in cerebral blood flow. Prior section of the cervical cord prevented both the increase in cerebral blood flow and the systemic hypertension. Alteration of cerebral perfusion pressure by bleeding during the hyperaemia in a further group of animals suggested that autoregulation was at least partially preserved during this phase. After maximum hyperaemia had occurred, however, autoregulation appeared to be lost. The clinical implications of these findings are discussed.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    I. Cisterna magna infusion in primates