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Interactions of L-dopa and amantadine in patients with Parkinsonism
  1. B. Cox,
  2. G. Danta1,
  3. H. Schnieden,
  4. G. M. Yuill
  1. Department of Neurology, Manchester Royal Infirmary, University of Manchester
  2. The Department of Pharmacology, University of Manchester


    Twenty-seven patients with Parkinson's disease participated in a double-blind crossover trial of L-dopa and amantadine. Each drug was given for six weeks, and six weeks were allowed to elapse between the two periods of treatment. Marked improvement occurred in patients given L-dopa first, whereas no clinical effect was observed in those patients treated first with amantadine. L-dopa was less beneficial to patients who had previously received amantadine, whereas amantadine became effective in patients who had previously taken L-dopa. The effect of pre-treatment with one drug on the therapeutic effectiveness of the other drug is reflected in changes of homovanillic acid levels in the cerebrospinal fluid.

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