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Limbic dementia
  1. Generoso G. Gascon,
  2. Floyd Gilles
  1. Department of Neurology, Harvard Medical School, Massachusetts, U.S.A.
  2. Department of Neuropathology, Harvard Medical School, Massachusetts, U.S.A.
  3. The Children's Hospital-Peter Bent Brigham-Beth Israel Neurology Residency Program, Boston, Massachusetts, U.S.A.


    This is the second reported case, known to the authors, of complete, but selective, limbic lobe destruction in previously normally functioning central nervous systems. Both cases had an amnestic syndrome, whose characteristics were essentially similar to amnestic syndromes previously documented with less complete limbic destruction, with one difference—confabulation remained a prominent feature in the chronic stages of the memory disorder. Our patient exhibited a behavioural syndrome similar to that reported by Klüver and Bucy in monkeys with bilateral anterior temporal lobectomies. Klüver-Bucy like syndromes in man have usually been reported with surgical lesions, usually in patients with pre-existent brain disorder. Our case illustrates that the syndrome can be produced by necrotizing encephalitic lesions. We suggest that the combination of the above two syndromes is essentially a `limbic dementia'.

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    • 1 This work was supported in part by funds provided by the United Cerebral Palsy Research and Educational Foundation (R-224-69), by the Program-Project Grant No. NSI-EP, 1 PO1 NS 09704-01 NSPA, HD, NINDS, and the Children's Hospital Medical Center Retardation and Human Development Research Program (HD 03-0773), NICHD.