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Creutzfeldt-Jakob disease treated with amantidine
  1. W. L. Sanders,
  2. T. L. Dunn
  1. Central Hospital, Hatton, Warwick

    A report of two cases


    The treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral.

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    A report of two cases

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