You are here

Article Text

Article menu
Download PDFPDF
Articles
Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid
  1. E. Garelis,
  2. T. L. Sourkes
  1. Laboratory of Chemical Neurobiology, Department of Psychiatry, McGill University, Montreal, Quebec, Canada

    Abstract

    The concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5-HIAA) were measured in five cases with partial or complete block of CSF circulation, at various levels. Determinations were made in both a lumbar and a cisternal, or `mixed', sample obtained during pneumoencephalography. Most of the HVA appears to enter the ventricular system at the lateral ventricles, whereas much of the 5-HIAA in CSF originates in lower neuronal structures, including the spinal cord. The spinal contribution to the 5-HIAA content of lumbar CSF is of the order of 23-37%.

    https://doi.org/10.1136/jnnp.36.4.625

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

      Footnotes

      • ↵1 This investigation received financial support from the World Health Organization, through a grant to E. Garelis, and from the Medical Research Council (Canada) through a grant to T. L. Sourkes.