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Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid
  1. E. Garelis,
  2. T. L. Sourkes
  1. Laboratory of Chemical Neurobiology, Department of Psychiatry, McGill University, Montreal, Quebec, Canada


    The concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5-HIAA) were measured in five cases with partial or complete block of CSF circulation, at various levels. Determinations were made in both a lumbar and a cisternal, or `mixed', sample obtained during pneumoencephalography. Most of the HVA appears to enter the ventricular system at the lateral ventricles, whereas much of the 5-HIAA in CSF originates in lower neuronal structures, including the spinal cord. The spinal contribution to the 5-HIAA content of lumbar CSF is of the order of 23-37%.

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    • 1 This investigation received financial support from the World Health Organization, through a grant to E. Garelis, and from the Medical Research Council (Canada) through a grant to T. L. Sourkes.