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Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion
  1. K. M. A. Welch,
  2. Kazuo Hashi,
  3. John Stirling Meyer
  1. Department of Neurology, Baylor College of Medicine, Houston, Texas 77025, U.S.A.
  2. The Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas 77025, U.S.A.


    The effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (O2a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischaemic and non-ischaemic areas of brain. As a result of focal cerebral ischaemia, 5-HT may accumulate in the brain and contribute to the progression of infarction.

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    • 1 Supported by Grant No. NS 09287-01 from the National Institute of Neurological Diseases and Stroke.