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Biochemical aspects of motor neurone disease—Madras pattern
  1. K. Valmikinathan1,
  2. Mercy Mascreen,
  3. E. Meenakshisundaram,
  4. C. Snehalatha
  1. Institute of Neurology, Madras Medical College, Madras-3, India


    A detailed study of four cases of MND-Madras has shown a significantly low plasma citrate level in these subjects. Comparison with other related groups of neurological disorders indicates the citrate/pyruvate ratio to be of diagnostic value in MND-Madras. This seems to suggest that the pathophysiology of MND-Madras may centre round altered citrate metabolism.

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