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Anticholinergic withdrawal and benzhexol treatment in Parkinson's disease
  1. P. M. Horrocks,
  2. D. J. Vicary,
  3. J. E. Rees,
  4. J. D. Parkes,
  5. C. D. Marsden
  1. University Department of Neurology, Institute of Psychiatry, King's College Hospital, Denmark Hill, London


    The effects of slow withdrawal of anticholinergic medication and addition of benzhexol (8 mg/day) have been studied in patients with Parkinson's disease on stable levodopa therapy. Withdrawal of anticholinergic drugs led to measurable and often severe deterioration in about two-thirds of patients. Addition of benzhexol produced a slight but definite additional improvement in those patients in whom anticholinergics were withdrawn before the trial. Anticholinergic drugs thus still have a part to play in the treatment of Parkinson's disease, for they produce benefit in addition to that provided by levodopa.

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