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The cerebellum in mucopolysaccharidosis
  1. R. Doshi,
  2. S. A. Sandry,
  3. A. W. Churchill,
  4. Betty Brownell
  1. Burden Neuropathological Laboratory, Frenchay Hospital, Bristol

    A histological, histochemical, and ultrastructural study


    Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism. The results suggest that the demonstration of ovoid swellings of the Purkinje cell dendrites by the Cajal method for the cerebellum, together with certain histochemical findings, may enable a diagnosis of mucopolysaccharidosis to be made. Possible mechanisms for the formation of these swellings are briefly discussed.

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    A histological, histochemical, and ultrastructural study