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Differential cellular increase in cerebrospinal fluid after encephalography in mentally retarded patients
  1. M. Iivanainen,
  2. E. Taskinen
  1. Department of Neurology, University of Helsinki, Helsinki
  2. The II Department of Pathology, University of Helsinki, Helsinki
  3. The Department of Pathology, Aurora Hospital, Helsinki
  4. The Research Department, Rinnekoti Institution for the Mentally Retarded, Majalampi, Finland


    The behaviour of the CSF cells during gas encephalography (GEG) with O2, N2O, and halothane is poorly known in cerebral developmental disorders. One hundred and fifty CSF samples taken during pneumoencephalography from 75 mentally retarded patients were examined cytologically by the millipore technique with Papanicolaou staining. The results were processed automatically. An approximately 25-fold increase in CSF cells (P<0·001), mainly meningeal, reticulohistiocytic, and monocytic types, was found to occur. The cortical gas filling rate had a positive correlation (P<0·001) with the increase of number of CSF cells. There were no significant differences between the cellular changes in different cerebral disorders. Thus, though the irritant effect of GEG gives a rich cell yield, diagnostic atypical cells in developmental disorders of the central nervous system probably rarely exfoliate into the lumbar CSF.

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    • 1 National Welfare Association for the Mentally Deficient in Finland (Kehitysvammaliitto r.y.) provided financial support.