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An unusual intranuclear structure (? viral nucleocapsid) in the brain in subacute sclerosing panencephalitis
  1. A. D. Dayan1,
  2. Swati Majumdar,
  3. W. Hughes,
  4. K. W. G. Heathfield
  1. Department of Neuropathology, The National Hospitals, London
  2. Oldchurch Hospital, Romford


    A brain biopsy was examined from a 7 year old boy with subacute sclerosing panencephalitis. Intranuclear deposits of measles antigens were demonstrated in parenchymal cells by immunofluorescence. Electron microscopy showed viral nucleocapsids in nucleoliform inclusions and unusual rod-like intranuclear structures which resemble structures previously described only in tissue cultures infected with measles virus.

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    • 1 Present address: Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS.