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Phenytoin intoxication induced by sulthiame in epileptic patients
  1. G. W. Houghton,
  2. A. Richens
  1. Department of Clinical Pharmacology, St. Bartholomew's Hospital, London
  2. The National Hospital-Chalfont Centre for Epilepsy, Chalfont St. Peter, Bucks.

    Abstract

    Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.

    https://doi.org/10.1136/jnnp.37.3.275

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