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Cerebral blood flow and oxygen uptake, and cerebrospinal fluid biochemistry in severe coma
  1. Poul Brodersen2,
  2. Erik O. Jørgensen
  1. Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
  2. Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark
  3. Department of Anaesthesiology, Bispebjerg Hospital, Copenhagen, Denmark
  4. Department of Psychiatry, Bispebjerg Hospital, Copenhagen, Denmark
  5. Medical Department B, Rigshospitalet, Copenhagen, Denmark


    Thirty-eight patients in coma due to head trauma, cerebrovascular accidents, hypoxia, hypoglycaemia, or barbiturate intoxication, and 15 cases of brain death were studied. Cerebral metabolic rate of oxygen (CMRO2) was obtained from the arteriovenous oxygen difference and cerebral blood flow (CBF) measured by intra-arterial 133Xenon method. If hypothermia and CNS depressants were excluded, CMRO2 below one-third of normal was incompatible with regaining of consciousness, but this was seen in only three comatose patients. Irrespective of the clinical outcome (death, vegetative survival, or recovery), CMRO2 values of one-third to two-thirds of normal were seen in the majority of coma patients. CMRO2 measurements were of no practical value to predict the prognosis in coma, even when the effect of temperature and sedatives were considered. In brain death the CBF studies gave indirect evidence of cerebral circulatory arrest. The cerebrospinal fluid (CSF) was obtained for analysis of lactate, pyruvate, and bicarbonate in 29 cases. Increased CSF lactate levels were found in all groups except barbiturate intoxication. The finding of a negative correlation between CSF bicarbonate and log CBF suggests that the CSFpH determines the wide range of CBF in coma.

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    • 2 Address for correspondence: Dr. Brodersen, Department of Neurology, Bispebjerg Hospital, DK-2400 Copenhagen NV. Denmark.

    • 1 Read as a preliminary study before the Second International Symposium on Nuclear Medicine, Karlovy Vary, 13 May 1971, and before the 20th Congress of Scandinavian Neurologists, Oslo, 17 June 1972.