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Comparative trial of benzhexol, amantadine, and levodopa in the treatment of Parkinson's disease
  1. J. D. Parkes,
  2. R. C. Baxter,
  3. C. D. Marsden,
  4. J. E. Rees
  1. The University Department of Neurology, Parkinson's Disease Clinic, King's College Hospital, London
  2. The Maudsley Hospital, London


    Fourteen slightly disabled patients with Parkinsonism were treated separately with benzhexol, amantadine, and levodopa. Benzhexol and amantadine both gave a 15% reduction in functional disability and levodopa a 36% reduction. Benzhexol lessened the rigidity and improved the flexion of posture of Parkinson's disease, but had little or no effect on akinesia and tremor. Amantadine and levodopa caused improvement in all these symptoms. The combination of benzhexol and amantadine was as effective after four weeks of treatment as levodopa was after six months.

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