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Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects
  1. Barbara P. Hilton,
  2. K. J. Zilkha
  1. Department of Neurochemistry, Institute of Neurology, National Hospital, Queen Square, London


    Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.

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