In 20 cats a cold lesion of the cerebral cortex was produced to bring about a rise of intracranial pressure in order to establish the degree of difference in pressure between various compartments in the skull necessary to produce displacement of cerebral tissue. At certain pressures there was a shift of brain tissue in all animals. When the ventricular pressure increased further, in all animals the arterial pressure increased and in 15 cats we observed a periodic respiration at a mean value of 113·1±4·1 mmHg. All animals finally had a rapid respiration similar to central neurogenic hyperventilation.
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