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Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis
  1. L. E. Claveria1,
  2. G. Curzon,
  3. M. J. G. Harrison2,
  4. B. D. Kantamaneni
  1. Institute of Neurology, Queen Square, London


    Mean homovanillic acid and 5-hydroxyindoleacetic acid concentrations were significantly low in the lumbar CSF of a group of patients with disseminated sclerosis (DS) who were severely disabled but not in the CSF of a less severely restricted group with DS. CSF concentrations were also low in a group of patients with superior cerebellar peduncular tremor due to DS and in a single patient with a similar tremor associated with a post-traumatic brain-stem lesion. The interpretation of abnormal CSF amine metabolite concentrations is discussed in the light of these findings.

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    • 1 Present address: Ciudad Sanitaria, 1-Octubre, Madrid, Spain.

    • 2 Present address: Middlesex Hospital, Mortimer St., London W.1.

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