Article Text

Download PDFPDF

Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin
  1. Pamela M. Le Quesne,
  2. Valerie Goldberg,
  3. F. Vajda
  1. Medical Research Council Toxicology Unit, Carshalton Surrey
  2. The Department of Neurological Studies, The Middlesex Hospital, London
  3. The Department of Pharmacology, The Middlesex Hospital, London
  4. The Department of Chemical Pathology, Institute of Neurology, Queen Square, London


    Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.