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Long-term effect of glucocorticosteroids on neuromuscular blocking in mice.
  1. W F Arts,
  2. H J Oosterhuis


    The effect of dexamethasone, given thrice weekly, on neuromuscular blocking by D-tubocurarine was studied in mice. Dexamethasone antagonised the effect of D-tubocurarine. This antagonism developed gradually during the first two weeks of treatment. The possible relationship between this finding and the beneficial effect of glucocorticosteroids in patients with myasthenia gravis is discussed.

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