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Research Article
Effect of tinofedrine (Homburg D8955) on cerebral blood flow in multi-infarct dementia.
  1. J Merory,
  2. G H Du Boulay,
  3. J Marshall,
  4. J Morris,
  5. R W Russell,
  6. L Symon,
  7. D J Thomas

    Abstract

    Tinofedrine, a new derivative of l-norephedrine, was examined for cerebral vasodilator activity in man. Ten patients with reduced cerebral blood flow (CBF) and multi-infarct dementia were given the drug intravenously. Cerebral blood flow increased significantly by 28% from a mean of 43.3 to 55.5 ml/100 g/min.

    https://doi.org/10.1136/jnnp.41.10.900

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