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Tonic vibration reflex in Holmes-Adie syndrome: an electrophysiological study
  1. Giovanni Abbruzzese,
  2. Michele Abbruzzese,
  3. Emilio Favale,
  4. Sandro Ratto
  1. Department of Neurology, University of Genoa, Genoa, Italy


    The pathophysiological mechanisms underlying benign areflexia were studied in six patients with Holmes-Adie syndrome. No impairment of sensory conduction velocity of sural nerve was found. A normal tonic vibration reflex was obtained in all patients. H reflex was absent in five patients, but responses like F waves were recorded in three subjects. These findings suggest that muscle spindles are not affected and that spinal motoneurone excitability is normal.

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