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Cellular hypersensitivity to brain antigen in children of a family with hereditary ataxia
  1. R. S. Walls,
  2. D. V. Philcox,
  3. Catherine L. Cullis
  1. Clinical Immunology Service, Departments of Medicine and Neurology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa


    Sensitisation to brain antigen was demonstrated in eight of 24 clinically normal first generation children in a family with hereditary ataxia. This ratio is consistent with that expected in a dominantly inherited condition. It suggests that immunological reactivity may precede the clinical expression of disease, with important implications for presymptomatic diagnosis and for pathogenesis of degenerative disease.

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