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Nervous system complications of herpes zoster: immunofluorescent demonstration of varicella-zoster antigen in CSF cells
  1. A. C. B. Peters,
  2. J. Versteeg,
  3. G. TH. A. M. Bots,
  4. J. Lindeman,
  5. R. E. H. Smeets
  1. Department of Neurology, University Hospital, Leiden, The Netherlands
  2. Department of Pathology, University Hospital, Leiden, The Netherlands
  3. Department of Neuropathology, University Hospital, Leiden, The Netherlands
  4. The Laboratory of Medical Microbiology, University Hospital, Leiden, The Netherlands


    In nine out of 11 patients with herpes zoster and neurological symptoms varicella-zoster antigen was demonstrated in CSF cells by indirect immunofluorescent staining. Cerebrospinal fluid cytology was in most cases highly suggestive of viral infection. This study demonstrates the value of both immunofluorescent staining on CSF cells and CSF cytology, as corroboration of an otherwise exclusively serologically based virological diagnosis.

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