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Effect of lecithin on disability and plasma free-choline levels in Friedreich's ataxia.
  1. S Chamberlain,
  2. N Robinson,
  3. J Walker,
  4. C Smith,
  5. S Benton,
  6. C Kennard,
  7. M Swash,
  8. B Kilkenny,
  9. S Bradbury


    Four patients with Friedreich's ataxia took part in an open trial, in which they consumed 50-100g/day lecithin granules (containing approximately 22% phosphatidycholine) for 16 weeks, but no improvement resulted. Several unwanted effects including diarrhoea, nausea, depression, "hot flushes" and weakness were experienced. Resting levels of free-choline in plasma were within the range found in 19 normal subjects. Sixteen other patients with Friedreich's ataxia also had normal free-choline levels. Treatment with lecithin significantly increased plasma free-choline levels, but there was a trend for these to fall towards baseline levels, despite continued ingestion of lecithin.

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