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Amyotrophic lateral sclerosis: a double-blind crossover trial of thyrotropin-releasing hormone.
  1. K Imoto,
  2. K Saida,
  3. K Iwamura,
  4. T Saida,
  5. H Nishitani


    A double-blind crossover trial was conducted of thyrotropin releasing hormone treatment in six patients with amyotrophic lateral sclerosis. Patients received 4 mg of thyrotropin releasing hormone intramuscularly daily during the two-week treatment period. Although three patients reported subjective improvement, objective evaluation failed to demonstrate therapeutic effectiveness of thyrotropin releasing hormone in this dosage.

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