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Intravenous methylprednisolone for multiple sclerosis in relapse.
  1. M P Barnes,
  2. D E Bateman,
  3. P G Cleland,
  4. D J Dick,
  5. T J Walls,
  6. P K Newman,
  7. M Saunders,
  8. P J Tilley


    A randomised comparison is made between methylprednisolone, 1 g intravenously daily for 7 days, and a standard ACTH regime for the treatment of multiple sclerosis in acute relapse. It is found that methylprednisolone produces a more rapid clinical improvement than ACTH but confers no longer term benefit when the two treatments are compared at 3 months. It is proposed that intravenous methylprednisolone does have a role to play in the management of a patient with an acute relapse of multiple sclerosis.

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