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Research Article
Peripheral neuropathy during longterm high-dose amiodarone therapy.
  1. A G Fraser,
  2. I N McQueen,
  3. A H Watt,
  4. M R Stephens

    Abstract

    Three patients developed peripheral neuropathy after taking amiodarone for more than 18 months. All had high serum concentrations of amiodarone and its desethyl metabolite; in one patient concentrations in a sural nerve biopsy were 80 times higher than in serum. Peripheral neuropathy is a complication of large doses of amiodarone taken over long periods.

    https://doi.org/10.1136/jnnp.48.6.576

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