Article Text

Download PDFPDF

Controlled release levodopa treatment of motor fluctuations in Parkinson's disease.
  1. J L Juncos,
  2. G Fabbrini,
  3. M M Mouradian,
  4. C Serrati,
  5. A M Kask,
  6. T N Chase


    A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given every 2 hours. The results support the value of pharmaceutical approaches to the stabilisation of circulating levodopa levels in the treatment of Parkinson's disease.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.