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HLA and multiple sclerosis in south east Wales.
  1. R J Swingler,
  2. P F Kirk,
  3. C Darke,
  4. D A Compston
  1. Department of Neurology, University of Wales College of Medicine, Cardiff, UK.


    A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.

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