Article Text

Download PDFPDF
Paradoxical effects of temperature in multiple sclerosis.
  1. W P Honan,
  2. J R Heron,
  3. D H Foster,
  4. R S Snelgar
  1. Department of Neurology, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.


    Six cases of multiple sclerosis are reported in which cold produced a temporary exacerbation of symptoms and signs of the disease. Also, in one case investigated in detail by psychophysical methods, heating produced a paradoxical deterioration in vision and simultaneous improvement in sensory and motor function. The effect of temperature in multiple sclerosis is discussed and a physiological explanation for the paradoxical response to heating is suggested.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.