Article Text


Inhibition of vasopressin secretion during migraine.
  1. C J Poole,
  2. S L Lightman
  1. Medical Unit, Westminster Hospital, London, UK.


    Six subjects with a history of increased urinary frequency during migraine were studied. In each case there was a marked diuresis and natriuresis within 12 hours of onset of the headache. This was associated with a significant fall in urinary arginine vasopressin (AVP) (p less than 0.01). Migraine may be associated with altered hypothalamic activity resulting in reduced AVP secretion.

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