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Research Article
Adrenal cortex hormones in male epileptic patients before and during a 2-year phenytoin treatment.
  1. Z Ostrowska,
  2. B Buntner,
  3. D Rościszewska,
  4. I Guz
  1. Department of Pathophysiology, Silesian Medical Academy, Zabrze, Poland.

    Abstract

    Serum levels of progesterone, cortisol and phenytoin as well as the excretion of 17-OHCS were determined in 45 male epileptics before and during 24 months of the therapy. A significant decrease of the hormones was found in untreated patients. Phenytoin administration caused further decrease of cortisol and its metabolite 17-OHCS levels and a compensation of progesterone serum concentration.

    https://doi.org/10.1136/jnnp.51.3.374

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