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Parkinson's disease: an open label trial of pergolide in patients failing bromocriptine therapy.
  1. S A Factor,
  2. J R Sanchez-Ramos,
  3. W J Weiner
  1. University of Miami School of Medicine, Department of Neurology, Florida 33101.


    Sixty-three patients with Parkinson's disease who failed bromocriptine therapy for various reasons were treated in an open-label trial of pergolide. The data were evaluated in a retrospective manner. Forty-six percent had a good response and tolerated the pergolide. A comparison of the outcomes regarding response and toxicity revealed that bromocriptine and pergolide act differently in individual patients. A trial of pergolide in Parkinsonian patients failing bromocriptine therapy may be therapeutically useful.

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