Article Text

Download PDFPDF
The ontogeny of 3,4-dihydroxyphenylacetic acid in human cerebrospinal fluid.
  1. G M Anderson,
  2. M A Riddle,
  3. E L Hoder,
  4. F C Feibel,
  5. B A Shaywitz,
  6. D J Cohen
  1. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510.


    Measurement of cerebrospinal fluid (CSF) levels of the minor dopamine metabolite 3,4-dihydroxyphenylacetic acid in neonates and children indicates that a rapid decline (approximately 90%) occurs in the first 2 years of life. The much less rapid ontogenetic decline seen for the predominant dopamine metabolite, homovanillic acid (HVA), indicates that differing factors affect CSF levels of the two acid metabolites. Further study is required to determine which compound more closely reflects ontogenetic changes in dopamine functioning.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.