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Subacute administration of a TRH analogue (RX77368) in motorneuron disease: an open study.
  1. H Modarres-Sadeghi,
  2. H Rogers,
  3. J Emami,
  4. R J Guiloff
  1. Department of Neurology, Charing Cross and Westminster Medical School, Westminster Hospital, London, UK.


    Sixteen patients with motor neuron disease received RX77368, a TRH analogue, IV, repeatedly over 1-12 weeks (median 2 weeks). Slight to moderate improvement in bulbar function, particularly speech, was reproduced or persisted with repeated infusions in 8 of 12 responders over a median of 18 days (range 14-90) during the period of study. Cramps (5/9) and spasticity (5/8) improved for a median of 14 days (range 7-35) and 7 days (range 2-14) respectively. The highest benefit/side effect ratio was seen with 0.2 mg/kg (0.15 mg/kg in those with severe bulbar palsy) every 3-4 days. Long term studies with this analogue in MND are indicated.

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