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Tyrosine hydroxylase and levodopa responsive dystonia.
  1. N A Fletcher,
  2. I J Holt,
  3. A E Harding,
  4. T G Nygaard,
  5. J Mallet,
  6. C D Marsden
  1. Department of Clinical Neurology, Institute of Neurology, London, UK.


    It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.

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