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Research Article
People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.
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  1. B Sacks,
  2. S Smith
  1. Department of Psychiatry, Charing Cross and Westminster Medical School, London.

    Abstract

    The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

    http://dx.doi.org/10.1136/jnnp.52.11.1294

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