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People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.
  1. B Sacks,
  2. S Smith
  1. Department of Psychiatry, Charing Cross and Westminster Medical School, London.


    The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

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