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Regional cerebral blood flow by SPECT imaging in Sturge-Weber disease: an aid for diagnosis.
  1. C Chiron,
  2. C Raynaud,
  3. N Tzourio,
  4. C Diebler,
  5. O Dulac,
  6. M Zilbovicius,
  7. A Syrota
  1. Clinique de Pédiatrie et de Puériculture, Hôpital Saint Vincent de Paul, Paris, France.


    Regional cerebral blood flow (rCBF) was studied using SPECT (single photon emission computed tomography) with 133-Xenon in 13 patients with confirmed Sturge-Weber disease, aged 9 months to 18 years. CT scan, performed at the same time, showed evident cerebral angioma in 10 but not in three. A marked hypoperfused area was found in all patients, ranging from -32% to -72% and of the same location as the CT signs. The hypoperfusion seems to result from post ictal phenomenon as well as from chronic ischaemia. SPECT imaging is therefore a sensitive method for visualising intracranial angioma in Sturge-Weber disease and it provides an aid for diagnosis when a CT scan is not reliable.

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