Article Text

Download PDFPDF

A fulminant case of Guillain-Barré syndrome: topographic and fibre size related analysis of demyelinating changes.
  1. T Kanda,
  2. H Hayashi,
  3. H Tanabe,
  4. T Tsubaki,
  5. M Oda
  1. Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.


    In a necropsy case of early fulminant Guillain-Barré syndrome, demyelinating changes were observed throughout the peripheral nervous system, most conspicuous in the spinal nerve roots. The central/peripheral nervous system transition regions and most proximal zones of the roots escaped damage. In some root areas there were widespread early changes in myelin sheaths in the absence of significant infiltrates of inflammatory cells. In the fibre size analytical study, small myelinated fibres were preferentially involved.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.