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Complex partial status epilepticus associated with cyclosporin A therapy.
  1. R E Appleton,
  2. K Farrell,
  3. P Teal,
  4. S A Hashimoto,
  5. P K Wong
  1. Department of Paediatrics, University of British Columbia, Vancouver, Canada.


    Significant neurotoxicity including seizures, encephalopathy and coma may complicate the use of cyclosporin A (CyA). Two patients are described, receiving CyA, who presented with abnormal behaviour, stupor, focal motor activity and were shown to be in complex partial status epilepticus (CPSE). Abnormalities of behaviour and/or stupor in patients receiving CyA may be a manifestation of CPSE. Patients receiving CyA who develop an encephalopathy should have electroencephalography performed at the time of the abnormal behaviour.

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