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Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease.
  1. D Montaldi,
  2. D N Brooks,
  3. J H McColl,
  4. D Wyper,
  5. J Patterson,
  6. E Barron,
  7. J McCulloch
  1. Department of Psychological Medicine, Glasgow University, Glasgow, Scotland.


    Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to image 26 patients with dementia of the Alzheimer type (DAT) and 10 healthy controls. Regional cerebral blood flow (rCBF) data indicated a relative sparing of the occipital regions in DAT. Normalisation to occipital flow illustrated highly significant CBF deficits in a number of cortical regions, particularly in the left and right posterior--temporal cortex in DAT compared to controls. The cognitive performance of DAT patients was measured using a clinical cognitive assessment procedure (CAMCOG) and numerous correlations between these scores and rCBF were obtained. The implications and value of this investigative technique are discussed.

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