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Research Article
Platelet monoamine oxidase B activity in parkinsonian patients.
  1. U Bonuccelli,
  2. P Piccini,
  3. P Del Dotto,
  4. G M Pacifici,
  5. G U Corsini,
  6. A Muratorio
  1. Institute of Clinical Neurology, University of Pisa, Italy.

    Abstract

    Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

    https://doi.org/10.1136/jnnp.53.10.854

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