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Research Article
Nasogastric and intravenous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) in Parkinson's disease.
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  1. R J Coleman,
  2. N P Quinn,
  3. M Traub,
  4. C D Marsden
  1. Institute of Neurology, Queen Square, London, United Kingdom.

    Abstract

    (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) is a new dopamine agonist which is capable of producing a sustained response in parkinsonian patients with "on-off" fluctuations when given as a continuous infusion either nasogastrically or intravenously. These data suggest that a sustained release formulation of PHNO may provide a significant, new treatment for patients with "on-off" fluctuations.

    http://dx.doi.org/10.1136/jnnp.53.2.102

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